Isaac married Eleanora Maria Caroline TYLER on 3 Feb 1846 in St Mary, Lambeth, Surrey. Eleanora (daughter of John TYLER and Elizabeth HANDCOCK) was born in 1821 in Bermondsey, London; died in 1892 in St Saviour, Southwark, London. [Group Sheet] [Family Chart]

1. William John Tyler NEALE was born in 1847 in Newington, London; died in 1849 in Bermondsey, London; was buried on 29 May 1849 in St Mary Magdalene, Bermondsey, Surrey.
2. Charles Isaac NEALE was born in 1849 in Bermondsey, London; died in 1851.
3. George NEALE was born in 1850 in Bermondsey, London; died in 1853 in Newington, London.
4. Charles Henry Isaac NEALE was born in 1854 in Newington, London; died in 1897 in Camberwell, London; was buried on 15 Mar 1897 in Camberwell Old Cemetery, Southwark, London.